Dr.Singkome Tima
Dr. Singkome Tima, M.Sc. (Medical Technology) Member and secretary of AMS Cancer Research Unit and MT Cancer research Unit, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand. Mr. Singkome Tima is a medical technologist of Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences at the Chiang Mai University, Thailand. He received a Master degree of Science in Medical Technology from Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University. Now, he is a Ph.D. candidate from the Program of Nanoscience and Nanotechnology, Graduate School, Chiang Mai University. His doctoral research involves in preparation and evaluation curcumin nanoparticles as a drug delivery system (DDS) for targeted therapy of leukemia. He spent some parts of his thesis research at School of Pharmacy, The University of Kansas, USA, to design the FLT3-specific peptides and formulate the FLT3-specific curcumin nanoparticles. His research of interest is focused on cancer treatment, cancer targeting, especially leukemia, using various types of nonocarrier systems.
Book
1. Songyot Anuchapreeda, Sawitree Chiampanichayakul, Singkome Tima. Cell Morphology. 4th Edition, Santipab Pack-Print Co. Ltd. Kaeo Nawarat Rd., Wat Ket, Mueang Chiang Mai, Chiang Mai, 50000, Thailand, 2015. 220 pp.
2. Sawitree Chiampanichayakul, Songyot Anuchapreeda, Nutjeera Intasai, Singkome Tima. Body fluids. Santipab Pack-Print Co. Ltd. Kaeo Nawarat Rd., Wat Ket, Mueang Chiang Mai, Chiang Mai, 50000, Thailand, 2015. 208 pp.
Communications
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Selected current projects
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Research Interests
1. Nanotechnology, drug delivery system (DDS), and drug targeting for cancer therapy
2. Molecular biology of cancer
3. Oncogenes and tumor markers
4. Leukemic stem cell and leukemia markers
5. Cell signaling cascades in leukemia
6. Natural product research; mechanism of dietary herbs for cancer and leukemia therapy
Research Patents
1. Okonogi S, Anuchapreeda S, Tima S. Process of nano-curcumin production. Patent No. 1601003847, Date 28/06/2016, Thailand. (Submitted)
Research Publications
1. Mundee Y, Semsri S and Tima S. Evidence of platelet activation in the plasma of -thalassemia major patients. J Med Tech Phy Ther. 15 (Suppl. 1): S 123, 2003.
2. Mundee Y, Semsri S, Naksawat T, Tima S. A proposed composition of anti-coagulant and anti-platelet activation studies. J Med Tech Phy Ther. 16: 78-86, 2004.
3. Mundee Y, Naksawat T and Tima S. Evidence of endothelial activation in -thalassemic plasma obtaining from Maharaj Nakorn Chiang Mai Hospital. Bull Chiang Mai Assoc Med Sci 2005, 38: 124-29.
4. Anuchapreeda S, Wikan N, Tima S, Thanarattanakorn P, Sittipreechacharn S, Limtrakul P. Effect of curcumin on WT1 gene expression in human leukemic cells. J Med Tech Assoc Thailand. 33 (3):1252-64, 2005.
5. Anuchapreeda S, Thanarattanakorn P, Sittipreechacharn S, Tima S, Chanarat P. Limtrakul P. Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells. Arch Pharm Res. 29 (10): 866-873, 2006.
6. Anuchapreeda S, Maiprasert K, Tima S, Limtrakul P. Effect of Curcuminoids on MDR Phenotype in Human Embryonic Kidney Cell Lines. Srinagarind Med J. 22 (4): 425-433, 2007
7. Anuchapreeda S, Tima S, Duangrat C, Limtrakul P. Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines. Cancer Chemother Pharmacol. 62: 585-594, 2008.
8. Tima S, Phanphuech B, Anuchapreeda S. Cytotoxic study of Houttuynia cordata Thunb crude extracts on HL-60 and Molt4 leukemic cell line. Bull Chiang Mai Assoc Med Sci. 43 (1): 30-38, 2010.
9. Chueahongthong F, Ampasavate C, Okonogi S, Tima S, Anuchapreeda S. Cytotoxic effects of crude kaffir lime (Citrus hystrix, DC.) leaf fractional extracts on leukemic cell lines, J Med Plant Res. 5(14), 3097-3105, 2011.
10. Semsri S, Sweeney C, Intasai N, Jomgeow T, Tima S, Limtraku P, Anuchapreeda S. Pure curcumin inhibits exogenous WT1 (+/+) isoform protein via degradation pathway and protein kinase C in transfected U937 cells. African J of Pharmacy and Pharmacology. 5(16): 1846-1856, 2011.
11. Tima S, Donlei G. Preparation of crude red kidney bean extract for growth stimulation and cell division of peripheral blood mononuclear cells. Bull Chiang Mai Assoc Med Sci. 45, 23-31. 2012.
12. Phongpradist R, Chiampanichayakul S, Tima S, Siahaan T, Berkland C, Anuchapreeda S, Ampasavate C. Potential cIBR-Conjugated PLGA Nanoparticles for Selective Targeting to Leukemic Cells. World Academy of Science, Engineering and Technology. 66, 252-260, 2012.
13. Tima S, Ichikawa H, Ampasavate C, Okonogi S, Anuchapreeda S. Inhibitory Effect of Turmeric Curcuminoids on FLT3 Expression and Cell cycle Arrest in the FLT3-Overexpressing EoL-1 Leukemic Cell Line. J Nat Prod. 77(4), 948-954, 2014.
14. Sangkaruk R, Tima S, Rungrojsakul M, Chiampanichayakul S, Anuchapreeda S. Effects of Saraphi (Mammea siamensis) flower extracts on cell proliferation and Fms-like tyrosine kinase 3 expression in leukemic EoL-1 cell line. Bull Chiang Mai Assoc Med Sci. 49(2), 286-293, 2016.
15. Tima S, Okonogi S, Ampasavate C, Pickens C, Berkland C, Anuchapreeda S. Development and Characterization of FLT3-Specific Curcumin-Loaded Polymeric Micelles as a Drug Delivery System for Treating FLT3-Overexpressing Leukemic Cells. J Pharm Sci. 2016.